Laboratory of Virology (PW)

Personnel:
Head of the Laboratory: Andrzej Piasek, Ph.D.
phone.: 022 841 40 71 ext.464,

Employee:
Andrzej Lipniacki M.Sc.,
phone.: 022 841 40 71 ext.464,

Activities:

Educational acivity:

  • providing of M.Sc.courses
  • providing of summer laboratory school for university students

Research:

Statutory projects:
Investigation of antiviral activity of derivatives of 2,3, dideoxy 3, fluorotymidine in laboratory model of HIV replication.
Assisted conception in serodiscordant couples (where man is HIV positive and woman HIV negative).
Projects funded by European Communities (FP5RTD)
Designing of novel inhibitors of HCV RNA helicase-potential antyvirals for treatment and protection against C virus-induced diseases" project no: QLRT-2001-01079

Cooperation:

  • Laboratory of Antimetabolites, Institut of Biochemistry and Biophisics PAS
    Warszawa, ul. Pawińskiego 5a
    Head: Professor Tadeusz Kulikowski.
    (EU grant)
  • Bernhard Nocht Institut fur Tropical Medicine, Department of Virology
    Bernhard Nocht Str. 74, 20359 Hamburg, Germany
    Head: Dr. Peter Borowski
    (EU grant)
  • Freie Universitat Berlin
    Takustr. 6, 14195 Berlin, Germany
    Head: Prof. Wolfram Saenger
    (EU grant)
  • Institut National de la Sante et de la Recherche Medicale, INSERM Unit 271,
    (INSERM), 151 Course Albert Thomas, 69003 Lyon, France
    Head: Prof. Ch. Trepo
    (EU grant)
  • Obstetric-gynecological Clinic (Klinika Położnictwa i Ginekologii Instytutu Matki i Dziecka) - Mother and Child Institute
    01-211 Warszawa, ul. Kasprzaka 17a
    Head: Dr. Tomasz Niemiec
    (assisted conception)
  • Faculty of Biology of Warsaw University, Faculty of Chemical and Process Engineering of Warsaw University of Technology, Faculty of Agriculture and Biology of Warsaw Agricultural University
    (M.Sc. courses)

Services:

  • estimation antiviral activity (anty-HIV) of investigated compounds in cell lines.
  • estimation of cytotoxicity of investigated compounds in cell lines.

Equipment:

  • reverse microscope Olympus
  • laminar air flow
  • CO2 incubator
  • centrifuges, heat blocks and other small laboratory equipment

Publications since 2002:

  • Lipniacki A., Piasek A.: Diagnostyka laboratoryjna zakazeń HIV. Przegl
    Lek 2003, 60 (7):478-484
  • Lipniacki A., Piasek A.: Nowe leki antyretrowirusowe w leczeniu zakazen
    HIV. Przegl Lek 2003 , 60 (8):536-541
  • Lipniacki A.: Drug resistance as the primary cause of therapeutic failures in HIV/AIDS. HIV AIDS Rev, 2003; 2(2): 80-85
  • A. Miazga; N.E Poopeiko; A. Piasek; M. A. Siwecka; T. Kulikowski.: 5'-O-Ester Prodrugs of Potent and Selective Anti-HIV Agent - 2',3'-Dideoxy-3'-fluoro-2-thiothymidine (S2FLT): Synthesis and Anti-HIV Activity. Nucleosides Nucleotides Nucleic Acids 2003 Oct, 22(5-8):805-7
  • A. Miazga; K. Felczak; M. Bretner; M. A. Siwecka; A. Piasek; T. Kulikowski.: Thiated Analogues of 2',3'-Dideoxy-3'-fluorothymidine and Their Phosphorylated and Phosphonylated Derivatives: Synthesis, Interaction with HIV Reverse Transcriptase, and In Vitro Anti-HIV Activity. Nucleosides Nucleotides Nucleic Acids 2003 Oct, 22(5-8):973-6