DEPARTMENT OF BASIC AND APPLIED PHARMACY (PS)
Personnel and structure:
phone: 022- 851-43-85, 022- 022-841-18-88 ext. 369; ;
Secretary:
Ewa Zacharzewska, phone: 022-022-841-18-88 ext. 372
Beata Studzińska, phone: 022-022-841-18-88 ext. 372
Małgorzata Iwańczak, phone: 022-022-841-18-88 ext. 372
Mass Spectrometry Lab:
Zdzisław Chilmonczyk, Professor, phone: 022-841-18-88 ext. 397
Janina Witowska-Jarosz, M.Sc. phone: 022-841-18-88 ext. 397;
Chemical Analysis Lab I:
Barbara Kwiatkowska-Puchniarz, M.Sc.; phone: 851-52-24, 022-841-18-88 ext. 391
Anna Kulik, M.Sc.; phone: 022-841-18-88 ext. 374
Wanda Białecka, M.Sc.; phone: 022-841-18-88 ext. 375
Marzena Podolska, M.Sc.;phone: 022-841-18-88 ext. 375
Ewa Borecka-Kurzyk, phone: 022-841-18-88 ext. 375
Iwona Hartman, phone: 022-841-18-88 ext. 374
Chemical Analysis Lab II:
Elżbieta Kublin, Ph.D., phone: 851-52-38, 022-841-18-88 ext. 354
Krystyna Czerwińska, M.Sc.; phone: 022-841-18-88 ext. 368
Barbara Kaczmarska-Graczyk, M.Sc., phone: 022-841-18-88 ext. 397
Elżbieta Wyszomirska, M.Sc., phone: 022-841-18-88 ext. 368
Ewa Malanowicz, M.Sc.; phone: 022-841-18-88 ext. 368
Anna Pejaś, M.Sc.,phone: 022-841-18-88 ext. 368
Anna Zajączkowska, M.Sc., phone: 022-841-18-88 ext. 367
Małgorzata Sysło, phone: 022-841-18-88 ext. 367
Chemical Analysis Lab III:
Elżbieta Żelazowska, Ph.D.,phone: 851-52-25, 022-841-18-88 ext. 396
Anna Bogdan, M.Sc., phone:022-841-18-88 ext. 394
Anna Chyła, M.Sc.,phone:022-841-18-88 ext. 395;
Ewa Duszak, M.Sc., phone:022-841-18-88 ext. 395
Beata Zabrzewska, M.Sc., phone:022-841-18-88 ext. 371
Monika Guzera, M.Sc., phone:022-841-18-88 ext. 394
hysico-Chemical Lab:
Anna Jończyk, Ph.D., phone:851-52-42, 022-841-18-88 ext. 390
Małgorzata Lisowska-Kuźmicz, M.Sc., phone:022-841-94-35,022-841-18-88 ext. 349;
Małgorzata Kantor-Boruta, M.Sc.,phone:022-841-94-35, 022-841-18-88 ext. 389
Lina Walkowska, phone: 022-841-94-35, 022-841-18-88 ext. 378;
Danuta Cieślik, phone: 022-841-94-35, 022-841-18-88 ext. 387
Aleksandra Szczotkowska, M.Sc.;phone: 022-841-94-35, 022-841-18-88 ext. 387
Janusz Zieliński, phone:022-841-94-35, 022-841-18-88 ext. 389
Physical methods Lab:
Nina Sadlej-Sosnowska, Ass.Professor., phone: 022-841-94-35 ext.348
Agnieszka Ocios, M. Sc., phone: 022-841-94-35 ext.350
Activities:
Quality control and research of medicinal products covers:
Testing as a part of registration, post-registration, batch control, complains, arbitrate analysis, etc.The control activities cover various therapeutic groups of medicinal products: psychotropic, anticonvulsant, antimigraine, anti-arrhythmic, hypotensive, antiasthmatic, antitussive, antihistaminic, anticoagulant, anticancer, antimycotic, analgesic, antiviral, steroids with contraceptive action, hormones .
Both active and not active ingredients, raw materials as well as pharmaceutical dosage forms are tested and evaluated. Those tests include identity of ingredients, purity, desintegration, dissolution, dose uniformity, aerodynamic measurements of particles, etc.
The control-research activity is a part of national program that assures good quality of marketed medicines, proper bioavailability and therapeutical efficacy.
The categories of dosage in pharmaceutical forms tested are : tablets, capsules, transdermal systems, aerosols, ointments, creams, globules, solutions.
Tests are performed with the use of a wide variety of classical and instrumental analytical methods.
The main analytical techniques are: HPLC, spectrophotometry, gass chromatography, TLC, spectroscopy (UV-VIS, IR), spectropolarimetry and electrochemical methods.
The Mass Spectrometry Laboratory performs identification tests based on mass spectra with the use of ionization techniques like EI, CI, APCI and also electrospray (ESI).
We provide also support to the Drug Regulatory Authority through evaluation of the documentation for medicines being authorized for therapeutic use in Poland.
The research activity is focused on elaboration of the new analytical methods and elucidation of mechanisms of drugs interactions at the molecular level. The quality system according to PN-EN ISO/IEC 17025 is being introduced. Documents of quality systems are being elaborated. Used methods are validated. Equipment is calibrated according to the settled program. PTS (Proficiency Testing Studies) are carried out in the department to prove high quality of the performed tests.
Equipment:
HPsystems with UV, spectrofluorometric, refractometric, conductometric, DAD detection,SpeLC ctroscopic equipment: spectropolarimeter, refractometr, FTIR spectroscope,
Several dissolution units,
Gas chromatographes,
Spectrophotometers UV/VIS
Viscosimeters,
Titrators,
Impactors and impingers - measurement of particles size distribution, aerodynamic diameter and dose uniformity (inhalers, nebulizers and nasal sprays),
Densitometer (TLC)
Publications:
- A.P.Mazurek, N.Sadlej-Sosnowska, "Studies on tautomerism in tetrazole: comparison of Hartree-Fock and density functional theory quantumchemical methods"-Chemical Physics Letters 330 (2000) 212-218.
- A.Jończyk, Z.Nowakowska, "Determination of hydrochlorothiazide, triamterene and
propranolol hydrochloride by the spectrophotometric method and high-performance liquid chromatography (HPLC)"-Acta Poloniae Pharmaceutica vol.58, No. 5 pp. 339-344, 2001. - K.Czerwinska, E.Wyszomirska, T.Kaniewska,"Identification and determination of selected medicines reducing hipertention by densitometric and gas chromatographic methods"-Acta Poloniae Pharmaceutica vol.58, No. 5 pp. 331-338, 2001.
- M.Podolska, W.Białecka, B.Kwiatkowska-Puchniarz, "Intrinsic activity and comparative molecular dynamics of buspirone analogues at the 5-HT1A receptors"- Acta Poloniae Pharmaceutica 67, 2004, 2219-2230.
- N. Sadlej-Sosnowska, "Mutual relationships between magnetic aromaticity indices of
heterocyclic compounds"-Journal of Physical Organic Chemistry 2004, 17, 303-311. - Z.Chilmonczyk, L. Siennicki, B.Lozowicka, M.Lisowska-Kuźmicz , A.Jończyk, H.Y.Aboul Eneid "Structure-Retention Relationship in a series of chiral 1-4-Distributed Piperazine Derivativeson Carbohydrate chiral stationary phases", IL Farmaco 60, 2005, 439-443.
- Z.Chilmonczyk, H.Ksycińska, M.Lisowska-Kużmicz, A. Jończyk, M.Mazgajska, M.Jarończyk, A.Strzelczyk, H.Y.Aboul Eneid "Structure-enantioselectivity relationship of hypnotic-sedative 1,4- disubstituted piperazione derivatives on cellulose tris (4methylbenzoate) chiral stationary phase", Analytica Chimica Acta 556, 2005, 7-13.
- J.Krzek, J.S.Czekaj, W.Rzeszutko, A. Jończyk "Direct separation, identification and quantification of epimers 22R and 22S of budesonide by capillary gas chromatography on a short analytical column with Rtx-5 stationary phase", Journal of Chromatography B, 803, 2005, 191-200.
